Richard A. Bernstein, MD, PhD
Associate Professor, Stroke/Cerebrovascular

710 North Lake Shore
DriveAbbott Hall, 11th Floor
Chicago, IL, 60611
(312) 695-7950

A native of New York City, Dr. Bernstein attended the Bronx High School of Science, followed by Cornell University in Ithaca, NY, where he obtained a B.A. in biochemistry. As a participant in a combined MD/PhD program, he obtained a Ph.D. in molecular biology with Dr. Robert Roeder at The Rockefeller University, and then his medical degree from Cornell in 1996.

After an internship in internal medicine at Mt Sinai, in New York City, he was resident and chief resident in neurology at Columbia Presbyterian Medical Center, where he won teaching awards from the medical students all three years he was there. He completed fellowships in Neurovascular Critical Care and Stroke at UCSF and Stanford, respectively. While at Stanford, he won the Lysia Forno Award for resident teaching from the neurology residents.

Dr. Bernstein sees patients in both the hospital and outpatient settings with issues related to cerebrovascular disease. His research overlaps with his clinical interests and encompasses stroke prevention, acute stroke treatment, and neuroprotection after cardiac arrest.

Original Peer Reviewed Research Articles

• Bernstein, R. A., DeJong, J., and Roeder, R.G. Characterization of the highly conserved TFIIA small subunit from Drosophila melanogaster. J. Biological Chemistry (1994). 269: 24361-24366
• DeJong, J., Bernstein, R.A., and Roeder, R.G. Human general transcription factor TFIIA: Characterization of a cDNA encoding the small subunit and requirement for basal and activated transcription. Proc. Natl. Acad. Sci. USA (1995). 92: 3313-3317
• Kim, T.K., Zhao, Y., Ge, H., Bernstein, R.A., and Roeder, R.G. TATA-Binding protein residues implicated in a functional interplay between negative cofactor NC2 (Dr1) and general factors TFIIA and TFIIB. J. Biological Chemistry (1995). 270: 10976-10981
• Bernstein, R.A. Preinitiation complex assembly and general transcription factor TFIIA. Ph.D. Thesis. The Rockefeller University. (1995) New York, NY.
• Clarke, J.L., Johnston, S.C., Farrant, M., Bernstein, R.A, Tong, D., and Hemphill, J.C. External validation of the ICH score.Neurocritical Care (2004). Vol. 1, Number 1. p. 53-60.
• A.B. Naini, PhD; J. Lu, MD; P. Kaufmann, MD, MSc; R.A. Bernstein, MD, PhD;M. Mancuso,MD; E. Bonilla, MD; M. Hirano, MD; and S. DiMauro, MD. A novel mutation in the ND5 gene of mtDNA causing MELAS-MERRF overlap syndrome. Archives of Neurology  (2005). 62(3):473-6.
• Dubow, J., and Bernstein, R.A. Amplification of acute focal ischemic deficit by narcotics. In Press, Neurocritical Care.
• Adams, H.P., Effron, M.B., et al on behalf of the AbESTT-II Investigators. Emergency Administration of Abciximab for Treatment of Patients With Acute Ischemic Stroke: Results of an International Phase III Trial. Stroke (2008)). 39:87-99

Editorials, Reviews, Chapters, Commentaries

• Bernstein, R.A. Are TIAs Neuroprotective? Ischemic tolerance in human stroke. Neurobase (2000)(invited review) 
• Bernstein, R.A. and Hemphill, J.C. Critical care of acute ischemic stroke: in Current Neurology and Neuroscience Reports (2001). 1:587-592 (invited review)
• Bernstein, R.A, and Albers, G. Potential utility of DWI in cerebral venous thrombosis. Archives of Neurology(2001): 58; 1538 (invited commentary)
• Bernstein, R.A. Stroke: A practical Guide to Management by Warlow et al. JAMA (2001). 286: 724-725 (book review)
• Bernstein, R.A., and Albers, G. Caplan’s Stroke by Louis Caplan. JAMA (2001). 285:2383 (book review)
• Bernstein, R.A., and Alberts, M.J. Basal ganglia hemorrhage. Neurology Medlink(2002) (invited review)
• Bernstein, R.A. Uncommon causes of stroke, Bogousslavsky and Caplan eds. Archives of Neurology (2002). Vol. 59, p. 1492(book review)
• Bernstein, R.A., and Gress, D.R. Dural arteriovenous fistulas and the neurology of venous hypertension. Seminars in Cerebral Vascular Disease(2004). Vol 4; No. 4; p 168-175 (invited review, peer reviewed)
• Shaibani, A., Parkinson, R., Russell, E.J., Bendok, B.R., Bernstein, R.A., Walker, M., Wakhloo, A.K. Endovascular therapy of dural arteriovenous shunts. Seminars in Cerebrovascular Disease(2004). Vol 4, No.4; p. 176-194. (invited review, peer reviewed)
• Bernstein, R.A. Cerebrovenous Disease (Guest Editor). Seminars In Cerebrovascular Disease (2004). Vol. 4, No. 4.
• Das, S., Parkinson, R., Bernstein, R.A., Alberts, M.J., Shaibani, A., Batjer, H., and Bendok, B. Update on Carotid Artery Stenting, Part I. Contemporary Neurosurgery (2004). 26(13). (invited review, peer reviewed)
• Das, S., Parkinson, R., Bernstein, R.A., Alberts, M.J., Shaibani, A., Batjer, H., and Bendok, B. Update on Carotid Artery Stenting, Part II. Contemporary Neurosurgery (2004). 26(13). (invited review, peer reviewed)
• Bernstein, R.A., and Singhal, A. Post-partum angiopathy and other cerebral vasoconstriction syndromes. Neurocritical Care (2005). 3: 91-97 (invited review, peer reviewed)
• Bernstein, R.A., and Del Signore, M. Advances in management of acute intracerebral hemorrhage.Current Neurology and Neuroscience Reports (2005). 5: 483-487 (invited review, peer reviewed)
• Bernstein, R. A. (2006) Reversible Cerebral Vasoconstriction Syndromes. Current Treatment Options in Cardiovascular Medicine (2006). 8:3, 229-234 (invited review)
• Bernstein, R. A. (2006) Risk of stroke from non-cerebrovascular surgery in stroke patients. In press for: Neurologic Clinics of North America. 24(4) 777-82
• Bernstein, R.A. Hemorrhagic Stroke. In Current Diagnosis and Treatment: Neurology, J.C.M. Brust, ed.  (Lippincott-Williams, Publisher).
• Bernstein, R.A. Cholesterol Lowering After Stroke: Who, When, How. Current Treatment Options in Neurology 2006. 8 (6) 496-502
• Bernstein, R.A. Statin Therapy to Prevent Stroke Prevention in the Elderly. Current Current Cardiovascular Risk Reports.  In Press
• Corbridge, T.C., and Bernstein, R. A. Pharamacology of Respiratory Diseases.  In Interface of Neurology and Internal Medicine. J.Biller, Editor.
• Corbridge, T.C., and Bernstein, R. A. Chronic Obstructive Pulmonary Diease. In Interface of Neurology and Internal Medicine. J. Biller, Editor.
• Bernstein, R.A., and Schneck, M.J. Carotid Artery Angioplasty and Stenting. In Interface of Neurology and Internal Medicine. J. Biller, Editor.
• Bernstein, R.A. Antiplatelet agents for secondary prevention of stroke. Current Treatment Options in Cardiovascular Medcine. In press.

Case Reports, Letters

• Bernstein, R.A., Mayer, S.A., and Magnano, A. Neurogenic cardiac injury in             Guillain-Barre syndrome: case report. Neurology (2000). 54: 759-762

• Bernstein, R.A. and Bernardini G. Deep cerebral venous thrombosis presenting as dorsal midbrain syndrome. Neurology (2001). 56:424

• Warkentin, T.E., and Bernstein, R.A. Delayed-onset heparin-induced thrombocytopenia and cerebral thrombosis following a single administration of unfractionated  heparin; letter to the editor. New England Journal of Medicine (2003). 348 (11): 1067-1068

• Bernstein, R.A., Dowd, C.F. and Gress, D.R. Rapidly reversible dementia. Lancet (2003). 361; p. 392

• Bernstein, R.A. and Alberts, M.J. Redefining TIA (letter to the editor). New England Journal of Medicine (2003). 348 (16); 1607-1608

• Bernstein, R.A. and Futterer S. Venous unresponsiveness. Lancet(2004). 363:368

• Zeidman, L., Melen, O., Gottardi-Little, N., Getch, C., Alberts, M.J., Goldstein, L., and Bernstein, R.A. Susac syndrome with transient inverted vision. Neurology(2004). 63(3): 591

• Bernstein, R.A. Use of dipyridamole in patients with recent stroke or TIA (letter to the editor). Am Fam Physician (2005). Aug 1;72 (3):382, 3

• Fahey, C., Alberts, M.J., and Bernstein, R.A. Oral clopidogrel load in aspirin-resistant capsular warning syndrome: report of two cases, Neurocritical Care(2005). 2(2):183-4

• Anderson, C., Bergman, D.L., and Bernstein, R.A. Recurrent ischemic stroke during tPA infusion: case report. Neurocritical Care(2005). 3: 54-56.

• Bernstein, R.A., and Albers, G.W. Letter to the editor: Antiplatelet agents for stroke prevention. JAMA (2005). 293:793-794.

•  Nickele, C., Muro, K., Getch, C.C., Walker, M.T., and Bernstein, R.A.  Severe reversible cerebral vasoconstriction syndrome mimicking aneurysmal rupture and vasospasm. Neurocritical Care (2007). 7(1): 81-85

• Bernstein, R. Venous thromboembolism. Nature Clinical PracticeNeurology (2007) Oct. 3(10) 542-3

• Surdell D.L., Bernstein R.A., Hage Z.A., Batjer H.H., Bendok B.R. Symptomatic Spontaneous Intracranial Internal Carotid Artery Dissection Treated With a Self Expanding Intracranial Nitinol Stent: Case Report. Surgical Neurology (in press)

Abstracts and Research Presentations

• Clarke, J., Johnston, S. C., Bernstein, R.A., Tong, D.C., Hemphill III, J.C. (2002) External validation of the ICH score. Abstract, International Stroke Meeting (2002),
• Tong, D., Eyngorn, I., Bernstein, R.A., Wijman, C., Sullivan T., Moseley, M. Diffusion assessment of the genuine need for other studies in ischemic stroke (DIAGNOSIS): further observations. Abstract, International Stroke Meeting (2003).
• Tong, D., Eyngorn, I., Bernstein, R., Wijman, C., Sullivan, T., Schnittger, I., Moseley, M. Yield of TEE in patients with multiple infarcts on DWI. Abstract, International Stroke Meeting (2003).
• Alberts, M.J., Bernstein, R.A., Ramsey, G.E., Lindholm, P.F., Bergman, D.L., Soeding, M.E. Occurrence of aspirin resistance in patients hospitalized with stroke or TIA. Abstract, 5th World Stroke Congress (2003).
• Bernstein, R.A. Alberts, MJ, Soeding, M, Bergman, D., Jovanovic, B., Brooks, K. Lipoprotein (a) in acute ischemic stroke: A prospective study. Abstract, International Stroke Meeting. (2004).
• Curtin, K.R., Sakaie, K.E., Shin, W., Cashen, T.A., Khawar, S., Walker, M.T., Shaibani, A., Bernstein, R.A., Carroll, T.J. Quantitative cerebral blood flow measurement in recent stroke. Abstract, ANSR annual meeting  (2004).
• Bernstein, R.A., Alberts, M.J. Weinand, M., Ruland, S., Lowry,D., Dafer, R. Feasibility and safety of targeted cortical stimulation for enhancing motor recovery after ischemic stroke. Platform Presentation, American Academy of Neurology Annual Meeting. (2005).
• Alberts, M.J., Bergman, D., Brooks, K., Bernstein, R.A., Ramsey, G., and Lindholm, P. Clopidogrel resistance in patients with cerebrovascular disease. Abstract, International Stroke Meeting (2005).
• Shaibani, A., Shin, W., Khawar, S., Sakaie, K., Cashen, T., Bernstein, R. A., Carroll, T. Identification of ischemic thresholds for the infarct core and the ischemic penumbra utilizaing quantitative cerebral blood flow measurements by MRI imaging. Abstract, 43rd Annual Meeting of the American Society of Neuroradiology. (2005).
• Carroll, T., Shin, W., Khawar, S., Shaibani, A., Walker, M., Cashen, T., Bernstein, R.A., Sawlani, R., and Rohany, M. Quantification of cerebral blood flow in stroke. Abstract. 17th Annual International Conference on Magnetic Resonance Angiography  (2005).
• Lutsep HL and Bernstein RA.  Cortical stimulation for hemiparetic patients following stroke.  Abstract, American Neurological Association 130th Annual Meeting, (2005).
• Bernstein, R.A. and Lutsep, H.L. Motor cortex stimulation improves ipsilateral hemisphere-specific cognitive function after ischemic stroke. Abstract,American Academy of Neurology Annual Meeting, (2006).
• Bernstein, R.A., Liao, Y.J., Do, H.M., and Albers, G.W. Topography of acute brain infarction in CNS vasculitis using diffusion weighted imaging. Abstract,American Academy of Neurology Annual Meeting, (2006).
• Lutsep, H., and Bernstein, R. A. Cortical Stimulation for Hemiparetic Patients Following Stroke. Abstract,American Academy of Neurology Annual Meeting, (2006).
• Sheehan, J.J., Hitchell, A., Bernstein, R.A., Dill, K., Omary, R.A., Carr, J.C. Evaluation of patients with suspected cardioembolic stroke using cardiovascular MRI-a comparative study with echocardiography. Society of Interventional Radiology Annual Meeting (2006).
• Bernstein, R.A., Dewan, K., Naidech, A., Bergman, D., Oakley, R., Garrett, J., Fintel, D., Alberts, M.  Moderate hypothermia for anoxic encephalopathy after in-hospital and out-of-hospital cardiac arrest. European Stroke Conference, Glasgow, 2007
• Bernstein, R.A., Naidech, A.M., Garrett, J., Oakley, R., Bergman, D.L., Alberts, M.J., Fintel, D.J. Outcomes of moderate hypothermia for survivors of in-hospital and out-of-hospital cardiac arrest. Platform Presentation (anticipated). International Stroke Conference, New Orleans, LA. (2008)
• Bernstein, R.A., Conners, J., Sheehan, J.J., Lin, G., Dill K., Omary, R.A., Alberts, M.J., Carr, J.C. Therapeutic impact of cardiac MRI in patients with ischemic stroke. Poster, (anticipated), International Stroke Meeting, New Orleans, LA. (2008).

Other

• Bernstein, R. (2001) The neurologic illness of David Steinbrook; a case of dural arteriovenous fistula. Report for: The Wolf Run Foundation.
• Bernstein, R. A. Solving tough stroke cases in the ER. Practical Neurology 2004; 3(8) 30-34.