|
|
|
|
|
|


Lixin Kan, MD/PhD
Research Assistant Professor of Neurology
303 East Chicago Ave, Ward 10-233
Chicago, IL 60611
(312) 503-2793
|
| Background |
| Fellowship |
|
| Residency |
|
| Internship |
|
| Medical Degree |
MD: BengBu Medical College, Anhui, P.R. China
PhD: Medical School of Shanghai Jiao Tong University, P.R. China. |
|
Clinical
Interests |
|
| Research Interests |
|
| Biography |
Dr. Kan graduated from Bengbu medical college (China), a medical college close to his home town. He obtained his PhD at Medical School of Shanghai Jiao Tong Univeristy (previously known as Shanghai Second Medical University, China). He moved to Northwestern University in 1998 and was appointed Research Assistant Professor of Neurology in 2001.
Dr. Kan investigates how the fate of neural progenitor/stem cells is determined. He specifically focuses on one protein family called Sox B1 family genes (including Sox1, Sox2 and Sox3). His findings provide strong evidences to challenge the prevailing dogma in the field, which hypotheses that Sox B1 family genes all act in a similar way to keep cells in the progenitor/stem cells stage. Another focus of his research is on an animal model of Fibrodysplasia Ossificans Progressiva (FOP), a rare devastating connective tissue disorder. He received the Distinguished Service Award for this research. |
Selected
Publications |
- Kan L*, Jalali A, Zhao L, Zhou X, McGuire T, Kazanis I, Episkopou V, Bassuk AG, Kessler JA. Dual Function of Sox1 in Telencephalic Progenitor Cells. Developmental Biology (Dev Biol. 2007 Jul 27; [Epub ahead of print]. doi: 10.1016/j.ydbio.2007.07.026)
- Kan L*. The Neuron-Specific Enolase–Bone Morphogenic Protein 4 Transgenic Mouse A Fibrodysplasia Ossificans Progressiva-Like Animal Model. Clinical Reviews in Bone and Mineral Metabolism. 2005; 3: 235-237(Review)
- Kan L*, Kessler JA. New tool for an old problem: can RNAi efficiently resolve the issue of genetic redundancy? Bioessays. 2005 Jan;27(1):14-16 ( Review)
- Bonaguidi MA*, McGuire T, Hu M, Kan L, Samanta J, Kessler JA. LIF and BMP signaling generate separate and discrete types of GFAP-expressing cells. Development 2005 132, 5503-5514
- Kan L*, Hu M, Guha U, Gomes WA, Kessler JA. Transgenic Mice overexpressing BMP4 develop fibrodysplasia ossificans progressiva(FOP)-like phenotype. Am J Pathol. 2004; 165:1107-1115
- Guha U, Mecklenburg L, Cowin P, Kan L, O'Guin WM, D'Vizio D, Pestell RG, Paus R, Kessler JA*. BMP signaling regulates postnatal hair follicle differentiation and cycling. Am J Pathol. 2004; 165: 729-740
- Otero JJ*, Fu W, Kan L, Cuadra AE, Kessler JA*. β-catenin Signaling is Required for Neural Differentiation of Embryonic Stem Cells. Development 2004; 131: 3545-3557
- Israsena N, Hu M, Fu W, Kan L, Kessler JA*. The presence of FGF2 signaling determines whether β- catenin exerts effects on proliferation or neuronal differentiation of neural stem cells. Developmental Biology 2004; 268(1):220-231
- Chalazonitis A*, D’Autréaux F, Guha U, Pham TD, Faure C, Chen JJ, Roman D, Kan L, Rothman TP, Kessler JA, Gershon MD. Bone Morphogenetic Proteins -2 and -4 Limit the Number of Enteric Neurons but Promote Development of a TrkC-Expressing NT-3-Dependent Subset. Journal of Neuroscience 2004; 24(17):266-4282
- Kan L*, Israsena N, Zhang Z, Hu M, Zhao L, Jalali A, Kessler JA. Sox1 Acts Through Multiple independent Pathways to Promote Neurogenesis. Developmental Biology 2004; 269(2):580-594.
- Zhu Y, Kan L, Qi C, Kanwar YS, Yeldandi AV, Rao SM, Reddy JK*. Isolation and Characterization of Peroxisome Proliferator-Activated Receptor (PPAR) Interacting Protein (PRIP) as a Coactivator for PPAR. Journal of Biological Chemistry 2000; 275(18): 13510-13516
- Kan L, Jain S, Cook W, Cao W, Yeldandi AV, Rao SM, Yashpal S. Kanwar, and Janardan K. Reddy*. Cloning and Expression of the Murine Deoxyuridine Triphosphate Nucleotidohydrolase Gene: Differs from the Rat Enzyme in That it Lacks Nuclear Receptor Interacting LXXLL Motif. Gene Expression 1999; 8(4): 231-246
- Zhang T, Xiong H, Kan L, Zhang C, Jiao X, Fu G, Zhang Q, Lu L, Tong J, Gu B, Yu M, Liu J, Licht J, Waxman S, Zelent A, Chen E*, and Chen S*. Genomic Sequence, Structural Organization, Molecular Evolution, and Aberrant Rearrangement of Promyelocytic Leukemia Zinc Finger Gene. Proc.Natl.Acad.Sci.U.S.A.1999; 96:11422-11427
First author or equal first authors, * Corresponding author(s). |
|
|
 |
 |
|
|
|