|
Alexander H. Stegh, PhD
Assistant Professor - Zell Scholar
Department of Neurology
Phone: 312.503.2879
Fax: 312.503.5607
Email: a-stegh@northwestern.edu
Robert H. Lurie Comprehensive Cancer Center
Northwestern University Feinberg School of Medicine
Center for Genetic Medicine, Lurie Rm. 6-109 and 6-250 (lab)
303 E. Superior Street, Chicago, IL 60611-3015
|
|
|
Our research program is aimed at understanding the genetic program that underlies the pathogenesis of Glioblastoma multiforme (GBM), the most prevalent and malignant form of brain cancer. Applying a combination of cell/molecular biology, oncogenomic and mouse engineering approaches, we are dedicated to systematically characterize novel gliomagenic oncogenes and tumor suppressors. We will functionally delineate and validate these pathways towards pharmaceutical opportunities using sophisticated cell culture and animal models. More...
|
 |
| The Stegh lab was awarded with a Dixon Translation Award, and grants from the American Cancer Society Illinois, and the Stephen M. Coffman Charitable Trust.
|
| Read our latest publications:
Alexander H. Stegh (2012). Targeting the p53 signaling pathway in cancer therapy - the promises, challenges and perils. Expert Opin Ther Targets 16:67-83.
Fotini M. Kouri, Samuel A. Jensen, Alexander H. Stegh (2012). The Role of Bcl-2 Family Proteins in Therapy Responses of Malignant Astrocytic Gliomas: Bcl2L12 and Beyond. ScientificWorldJournal 2012:838916.
Glioma oncoprotein Bcl2L12 inhibits the p53 tumor suppressor. Genes and Development 24: 2194-2204
Beyond effector caspase inhibition: Bcl2L12 neutralizes p53 signaling in glioblastoma. Cell Cycle. 2011 10(1):33-8. |
| Stegh lab received James S. McDonnell 21st Century Science Initiative Award |
| Dr. Stegh received a Kimmel Scholar Award. |
| Stegh laboratory assumes leadership role in Northwestern’s Center of Cancer Nanotechnology Excellence Grant (NU-CCNE U54). Read more at http://www.ccne.northwestern.edu/ |
|
|
