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Vascular Neurology Research

Below are the labs and faculty who are focused on advancing knowledge of neurological vascular disease and stroke prevention, delivery of care and outcomes.

Labs

 Marc W. Slutzky Lab

Investigating ways to assist people with neurologic disorders through brain-machine interfaces.

Research Description

The goal of our research is to help people with neurologic disorders, especially those who are severely paralyzed from stroke, spinal cord injury, traumatic brain injury, or ALS. Our research centers around using neural prosthetics, i.e., human machine interfaces, to help restore or replace function of the injured nervous system. We have developed a myoelectric interface for neurorehabilitation training (MINT) to help people with stroke regain function in their arms. The MINT uses electrical muscle signals to control a cursor in customized video games. This enables them to improve coordination between the muscles.

Brain-machine interfaces (BMIs) offer the capability to “decode” brain signals and use them to control computer cursors, prosthetic limbs, or haptic feedback devices. We are investigating the possibility of using BMIs to help rehabilitate brain function by driving plasticity. We study this in humans with traumatic brain injury. In addition, we are investigating the potential to decode a person’s intended speech directly from his or her brain and using this to restore communication to people who have lost it due to severe paralysis. We also use this powerful paradigm to study the underlying relationship between different types of brain signals, for example, the relationship between field potentials (summed from many neurons in the network) and action potentials of individual neurons.

Publications

For more information see the faculty profile of Marc W Slutzky, MD/PhD or the Slutzky Lab website.

Contact Us

Marc W Slutzky, MD, PhD, at 312-503-4653

 Farzaneh Sorond Lab

Understanding neurovascular mechanisms responsible for acute and chronic brain injury.

Research Description

Our research program is directed at understanding neurovascular function in health and disease. Specifically, we have been studying the association between cerebral blood flow regulation, structural changes in the brain and the clinical outcomes of acute and chronic cerebrovascular injury. In acute neurovascular disorders, we have validated several novel indices of cerebral blood flow regulation which can now be used to predict the development of vasospasm in subarachnoid hemorrhage and hematoma expansion in patients with intraparenchymal hemorrhage. The availability of these early non-invasive biomarkers will have a significant impact on early interventions to improve outcome in patients with subarachnoid and intraparenchymal hemorrhage. Similarly, in chronic neurovascular disorders associated with aging and neurodegenration, we have been examining the contribution of vascular disease to mobility impairment and cognitive decline. We have shown that our non-invasive biomarkers of vascular function are strongly associated with cerebral small vessel disease as well as motor and cognitive impairment. Our goal is to expand these studies to include other neurological disorders such as stroke, pre-eclampsia, traumatic brain injury and dementia. Having non-invasive, real-time measure of neurovascular function which can predict clinical outcome in the early phases of brain injury will have significant implications on clinical trials and therapeutic targets designed for the treatment and prevention of these various acute and chronic neurovascular injuries.

For more information, view the faculty profile of Farzaneh A Sorond, MD, PhD. Visit her lab website here.

Recent Publications

View Dr. Sorond's full list of publications at Pubmed.

 

Faculty

Bernstein, Richard A

Bernstein, Richard A

Professor of Neurology (Stroke)

Bio

Neurovascular Critical Care, Stroke, Stroke of unknown cause, stroke in young people, acute stroke therapy, atrial fibrillation, stem cell therapy for stroke.

Caprio, Fan Z

Caprio, Fan Z

Assistant Professor of Neurology (Stroke)

Gorelick, Philip B

Gorelick, Philip B

Adjunct Professor of Neurology (Stroke)

Sorond, Farzaneh A

Sorond, Farzaneh A

Professor of Neurology (Stroke) and Neurology (Neurocritical Care)