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Northwestern University Feinberg School of Medicine
The Ken & Ruth Davee Department of Neurology
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Neurocritical Care Research

Below are labs and faculty working to understand neurocritical care disorders to improve outcomes for neurocritically ill patients.

To learn about ongoing clinical trials or participate in a study, visit the clinical trials page for our Division of Stroke & Neurocritical Care.

Labs

 Bleck Lab

His research interests include subarachnoid hemorrhage, intracerebral hemorrhage, head injury, status epilepticus, infections, neuromuscular respiratory failure, and the ICU management of the organ donor.

His research interests include subarachnoid hemorrhage, intracerebral hemorrhage, head injury, status epilepticus, infections, neuromuscular respiratory failure, and the ICU management of the organ donor. He has been involved in therapeutic temperature modulation research since 1999. He has played a key role several NIH-funded trials, including RANTAAS, RAMPART, ProTECT III, ESETT, iDef, EpiBios4Rx, GRASP, and SHINE.

For publications and more information, please see Dr. Bleck's faculty profile.

 

 Andrew Naidech Lab

Clinical and translational research of life-threatening neurological diseases, particularly brain hemorrhage.

Research Description

Intensive monitoring is a core function of an intensive care unit, and generates large amounts of data. In a neurologic unit, surveillance neuromonitoring is as important as vital signs and cardiac rhythm, yet there has been less clarity as to precisely what should be measured (biomarkers, imaging markers, serial examination scores) and its impact on complications and outcomes. We have established methods and models for the retrieval and analysis of data from the electronic health record for patients with stroke for a large registry that I have maintained over 10 years (Northwestern University Brain Attack Registry, NUBAR), which now includes >1,000 patients.

Research to improve patient outcomes is limited to endpoints we can reliably measure. Collaborating with Neuro-QOL, a platform for measuring Quality Of Life in neurological disorders, and the NIH Patient Reported Outcomes Measurement Information System (PROMIS) Statistical Center, we have shown web-based computer-adaptive testing by study staff, patients or family members are valid compared to the usual standard of a validated interview, have increased statistical power, and highlight aspects of HRQoL, such as cognitive function, that would otherwise be undetectable (supported by K23 HS023437). Further, these measures improve our statistical power to perform research that measurably improves patient-centered outcomes.

In a continuing project with Preventive Medicine faculty, we are using network analytic techniques to identify high-performing teams. Previous publications have established methods to identify which members of the health care team (e.g., physicians, pharmacists, nurses) interacted with the patient in the electronic health record. Then, a quantitative measure of the success of interactions is calculated on an outcome. In past research, likelihood to recommend scores were the outcome. Here, we used NUBAR’s recorded functional outcomes (e.g., independence, dependence, death), and established that the interactions of team members are an independent predictor of patient outcome after accounting for severity of injury. This research opens up new lines of research on how to design high-performing teams.

In short, the lab collaborates widely to leverage innovative techniques to improve treatments for patients with life-threatening neurologic injury.

Contact Information

Andrew Naidech, MD, MSPH, FANA

Professor of Neurology

 Farzaneh Sorond Lab

Understanding neurovascular mechanisms responsible for acute and chronic brain injury.

Research Description

Our research program is directed at understanding neurovascular function in health and disease. Specifically, we have been studying the association between cerebral blood flow regulation, structural changes in the brain and the clinical outcomes of acute and chronic cerebrovascular injury. In acute neurovascular disorders, we have validated several novel indices of cerebral blood flow regulation which can now be used to predict the development of vasospasm in subarachnoid hemorrhage and hematoma expansion in patients with intraparenchymal hemorrhage. The availability of these early non-invasive biomarkers will have a significant impact on early interventions to improve outcome in patients with subarachnoid and intraparenchymal hemorrhage. Similarly, in chronic neurovascular disorders associated with aging and neurodegenration, we have been examining the contribution of vascular disease to mobility impairment and cognitive decline. We have shown that our non-invasive biomarkers of vascular function are strongly associated with cerebral small vessel disease as well as motor and cognitive impairment. Our goal is to expand these studies to include other neurological disorders such as stroke, pre-eclampsia, traumatic brain injury and dementia. Having non-invasive, real-time measure of neurovascular function which can predict clinical outcome in the early phases of brain injury will have significant implications on clinical trials and therapeutic targets designed for the treatment and prevention of these various acute and chronic neurovascular injuries.

For more information, view the faculty profile of Farzaneh A Sorond, MD, PhD. Visit her lab website here.

Recent Publications

View Dr. Sorond's full list of publications at Pubmed.

 

 Ayush Batra Lab

Dr. Ayush Batra's lab is focused on his research interests in Neurology

Visit Dr. Batra's faculty profile for more information

 Matthew Maas Lab

Dr. Maas' research focuses on the detection and management of evolving neurologic symptoms in critically ill patients, with an emphasis on understanding the role of the circadian system and impaired brain arousal.

Visit Dr. Maas' faculty profile to learn more.

 Minjee Kim Lab

Dr. Minjee Kim's lab focuses on her research interests in neurology.

Visit Dr. Kim's faculty profile to learn more

 Eric Liotta Lab

Dr. Eric Liotta's lab focuses focuses on improving acute management of and outcomes from critical neurologic illness. His current primary focus is the management of severe hepatic encephalopathy in patients with fulminant, acute, and acute-on-chronic liver failure and noninvasive detection of cerebral edema.

Visit Dr. Liotta's faculty profile to learn more.

Faculty

Ansari, Sameer A

Ansari, Sameer A

Professor of Radiology (Neurointerventional Radiology), Neurological Surgery and Neurology - Ken and Ruth Davee Department

Bio

My clinical research interests include the endovascular treatment of neurovascular diseases, specifically advanced MRI techniques to optimize patient selection for acute ischemic stroke and intracrani... [more]

Batra, Ayush

Batra, Ayush

Assistant Professor of Neurology (Stroke and Neurocritical Care) and Pathology

Bleck, Thomas P

Bleck, Thomas P

Professor of Neurology (Stroke and Neurocritical Care) and Neurology (Epilepsy/Clinical Neurophysiology)

Bio

neurocritical care, status epilepticus, subarachnoid hemorrhage, neurogenic respiratory failure, intracerebral hemorrhage, Guillain-Barre syndrome, central nervous system infections, clostridial disea... [more]

Kim, Minjee

Kim, Minjee

Assistant Professor of Neurology (Stroke and Neurocritical Care)

Liotta, Eric M

Liotta, Eric M

Assistant Professor of Neurology (Stroke and Neurocritical Care) and Surgery (Organ Transplantation)

Bio

Dr. Liotta's research focuses on improving acute management of and outcomes from critical neurologic illness. His current primary focus is the management of severe hepatic encephalopathy in patients w... [more]

Maas, Matthew B

Maas, Matthew B

Associate Professor of Neurology (Stroke and Neurocritical Care) and Anesthesiology

Bio

Dr. Maas is a research neuroscientist, a medical educator, and a clinically active neurologist and critical care specialist. In his clinical practice, he manages high-risk injuries and diseases of the... [more]

Naidech, Andrew M

Naidech, Andrew M

Professor of Neurology (Stroke and Neurocritical Care) , Anesthesiology, Medical Social Sciences, Neurological Surgery and Preventive Medicine (Health and Biomedical Informatics)

Bio

I am committed to using data to improve patient care and patient outcomes, particularly using machine learning and electronic health records. I am board-certified in clinical informatics, neurology, v... [more]

Rosenow, Joshua M

Rosenow, Joshua M

Professor of Neurological Surgery, Neurology - Ken and Ruth Davee Department and Physical Medicine and Rehabilitation

Bio

Dr. Rosenow is the Director of Functional Neurosurgery in the Northwestern University Feinberg School of Medicine Department of Neurosurgery and at Northwestern Memorial Hospital. He specializes in th... [more]

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